Cytosolic glutathione s-transferases of ostrich liver.
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Date
2015-04-09
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Abstract
Chemicals consummumed by the ostrich are likely to be metabolised by liver detoxifying enzymes such as the cytosolic glutathione Stransferases
(GST). We have studied the affinity purified GST from male and female ostrich livers. 1-chloro-2, 4-dinitrobenzene
(CDNB) proved to be the best of several substrates tested to measme activity. Activity with this substrate was inhibited by
sulphobromoptgnalein and cibamon blue which are well established inhibitors for the m ammalian enzyme. A number of pesticides and
environmentai pollutants were also found to be strong inhibitors of the enzymes. Our data indicates that ostrich liver enzymes behave
similarly to the mammalian liver enzyme in terms of substrate requirements and inhibition characteristics.
Description
An article with 14 pages.
Keywords
cytosolic glutathione Stramfmes