Antimalarial Phytochemicals: Delineation of the Triterpene Asiatic Acid Malarial Anti-Disease and Pathophysiological Remedial Activities - Part I
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Date
2018-05
Journal Title
Journal ISSN
Volume Title
Publisher
Scholarena
Abstract
Malaria is a composite condition of the Plasmodium parasite infection and accompanying pathologies. Parasite induced red blood cell
perturbations and immunological response to infection drive various organ-specific syndromes accounting for a huge percentage of deaths
amongst children <5 years and pregnant women. The multi-factorial pathophysiology includes acute renal failure, hypoglycaemia, severe
malaria anaemia, acute respiratory distress syndrome/ acute lung injury and cerebral malaria as some of the prominent presentations of
the disease. Current malaria treatment has largely remained “anti-parasite” or “anti-infection” necessitating discovery of “anti-disease”
drugs that will ameliorate immunological aberrations, inflammation and metabolic disturbances which are ultimately the cause of high
morbidity and mortality. Asiatic acid, a phytochemical, has well known curative properties on other conditions which share disease
manifestations with malaria. However, the influence of Asiatic acid on malaria has not yet been reported. This review unravels the
different facets of Asiatic acid and their possible remedial effects on molecular and biological changes introduced by the disease with
emphasis on how this relates to glucose metabolism, acute renal failure, severe malaria anaemia, acute respiratory distress syndrome/
acute lung injury and cerebral malaria.
Description
Review article
Keywords
Asiatic Acid, Phytochemical, Malaria, Anti-Disease, Antioxidant, Ant-Parasitic, Anti-Disease
Citation
Mavondo, G. A., Kasvosve, I., 2017. Antimalarial Phytochemicals: Delineation of the Triterpene Asiatic Acid Malarial Anti-Disease and Pathophysiological Remedial Activities - Part I. J Infect Disease Pathol 1: 104