Effects of concurrent chloroquine and ethanol administration on the rat kidney morphology

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dc.contributor.authorAbdulkadir, Abdurrahman
dc.contributor.authorMbajiorgu, Ejikeme. F
dc.contributor.authorNyirenda, Trust
dc.date.accessioned2018-11-19T13:02:45Z
dc.date.accessioned2023-06-27T08:51:24Z
dc.date.available2018-11-19T13:02:45Z
dc.date.available2023-06-27T08:51:24Z
dc.date.issued2018-01-18
dc.descriptionopen access journal articleen_US
dc.description.abstractThe use of antimalarial chloroquine in malaria-endemic regions of Africa is rampant and it is not uncommon to find individuals taken the drug concurrent with alcohol. Effects of anti-malarial drug chloroquine (Chq) and ethanol (Et) combination on kidney volume and function using rat model was investigated. Methods: 32 adult male rats were randomly distributed into four groups of 8 rats each. Group C serve as control and received vehicle only, while Q is Chq treated only, E is Et treated and QE is Et and Chq treated. Chq was administered intraperitoneally at 1mg/100g body weight weekly and 6% Et in drinking water provided ad libitum. Urine volume was collected before the treatment began and after the treatment. After eight weeks, all animals were euthanized; kidneys were harvested and fixed in 10% neutral formalin. The fixed left kidneys were scanned with computed tomography and the scan slices were used to estimate 3-dimensional kidney volume on ImageJ. Results: Total kidney volume was none significantly increased in Q, E and QE treated compared to control groups (p = 0.5150). Also, microscopic analysis showed increased proximal tubule diameter (p = 0.1426) and epithelial hypertrophy (p = 0.2530) and significant urinary space shrinkage (p = 0.00001). The initial urine volume was not significantly different between the control and treated groups (p = 0.9864) however, following treatment urine volume was significantly reduced in QE rats group (p = 0.0029). Conclusion: The results suggest chloroquine and ethanol combination as potential cause of kidney injury through structural damage and function derangementen_US
dc.identifier.citationAbdulkadir, A, Mbajiorgu, E.F and Nyirenda, T. (2018).Effects of concurrent chloroquine and ethanol administration on the rat kidney morphology. Pan-African Medical Journal, 29 (49).en_US
dc.identifier.issn1937-8688
dc.identifier.urihttp://196.220.97.103:4000/handle/123456789/965
dc.language.isoenen_US
dc.publisherAfrican Field Epidemiology Networken_US
dc.subjectEthanolen_US
dc.subjectStereologyen_US
dc.subjectChloroquineen_US
dc.subjectComputed tomographyen_US
dc.subjectRelative medullary thicknessen_US
dc.titleEffects of concurrent chloroquine and ethanol administration on the rat kidney morphologyen_US
dc.typeArticleen_US
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