The effect of schistosomiasis on the covalent binding of 2-acetylaminofluorene to mouse liver macromolecules in vivo and in vitro
Loading...
Date
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier
Abstract
The covalent binding of [14C]acetylaminofluorene (AAF) to macromolecules in vivo and in vitro was measured in Schistosoma mansoni-infected and in non-infected mice. Liver microsomes from infected mice demonstrated a 42% decreased capacity to mediate covalent binding of AAF to DNA. In addition, the extent of binding of AAF to liver macromolecules in vivo was generally less in infected than non-infected mice.
Description
1. Sprague DH, Yang JC and Ngai SH, Effects of isoflurane and halothane on contractility and the cyclic 3', 5'-adenosine monophosphate system in the rat aorta. Anesthesiology 40: 162-170, 1974. 2. Aronstam RS, Anthony BL and Dennison RL Jr, Halothane effects on muscarinic acetylcholine receptor binding in rat brain. Biochem Pharmaco135: 667-672, 1986.
Citation
Siwela, A. H.; Nyathi, C. B.; Chetsanga, C. J.; and Hasler, J. A. 1990. The effect of schistosomiasis on the covalent binding of 2-acetylaminofluorene to mouse liver macromolecules in vivo and in vitro. Elsevier: Biochemical pharmacology Volume 40 Issue 2 Pages 379-382.