The effect of schistosomiasis on the covalent binding of 2-acetylaminofluorene to mouse liver macromolecules in vivo and in vitro

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dc.contributor.authorSiwela, Andrew H.
dc.contributor.authorNyathi, C.B.
dc.contributor.authorChetsanga, C.J.
dc.contributor.authorHasler, Julia A.
dc.date.accessioned2015-06-29T09:17:17Z
dc.date.accessioned2023-06-23T14:00:45Z
dc.date.available2015-06-29T09:17:17Z
dc.date.available2023-06-23T14:00:45Z
dc.date.issued1990-07-15
dc.description1. Sprague DH, Yang JC and Ngai SH, Effects of isoflurane and halothane on contractility and the cyclic 3', 5'-adenosine monophosphate system in the rat aorta. Anesthesiology 40: 162-170, 1974. 2. Aronstam RS, Anthony BL and Dennison RL Jr, Halothane effects on muscarinic acetylcholine receptor binding in rat brain. Biochem Pharmaco135: 667-672, 1986.en_US
dc.description.abstractThe covalent binding of [14C]acetylaminofluorene (AAF) to macromolecules in vivo and in vitro was measured in Schistosoma mansoni-infected and in non-infected mice. Liver microsomes from infected mice demonstrated a 42% decreased capacity to mediate covalent binding of AAF to DNA. In addition, the extent of binding of AAF to liver macromolecules in vivo was generally less in infected than non-infected mice.en_US
dc.description.sponsorshipResearch Support, Non-U.S. Gov't, In Vitroen_US
dc.identifier.citationSiwela, A. H.; Nyathi, C. B.; Chetsanga, C. J.; and Hasler, J. A. 1990. The effect of schistosomiasis on the covalent binding of 2-acetylaminofluorene to mouse liver macromolecules in vivo and in vitro. Elsevier: Biochemical pharmacology Volume 40 Issue 2 Pages 379-382.en_US
dc.identifier.otherDOI: 10.1016/0006-2952(90)90703-N
dc.identifier.urihttp://196.220.97.103:4000/handle/123456789/535
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofseriesBiochemical Pharmacology;Vol. 40, No. 2, pg. 379-382.
dc.subjectschistosomiasisen_US
dc.subjectcovalent bindingen_US
dc.subjectacetylaminofluoreneen_US
dc.subjectmouse liveren_US
dc.subjectmacromoleculesen_US
dc.subjectvivoen_US
dc.subjectvitroen_US
dc.subjectGene Ontologyen_US
dc.subjectSpeciesen_US
dc.subjectChemicalsen_US
dc.titleThe effect of schistosomiasis on the covalent binding of 2-acetylaminofluorene to mouse liver macromolecules in vivo and in vitroen_US
dc.typeArticleen_US
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