Evolution of antimicrobial resistance of Salmonella enteritidis (1972–2005)
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Date
2014-11-12
Journal Title
Journal ISSN
Volume Title
Publisher
AOSIS OpenJournals
Abstract
With the extensive use of antibiotics in livestock production, surveillance revealed an increase in salmonella resistance to the commonly used antimicrobials in veterinary and public
health. This serious threat to health care is further exacerbated by the limited epidemiological information about the common zoonotic agent, Salmonella enteritidis, required to determine
antibiotic therapy. The aim was to characterise the antimicrobial resistance patterns of S. enteritidis isolates across different timelines (1972–2005) with accompanying genetic changes being investigated. Thirty-seven stored S. enteritidis isolates were collected from
the Central Veterinary Laboratory, Harare, with antimicrobial susceptibility determined against eight antibiotics. Plasmids were isolated to analyse any genetic variation. An overall significant increase in resistance (p < 0.05) to nalidixic acid (0% – 10%), ampicillin (14.3% –50%), tetracycline (14.3% – 30%) and erythromycin (71.4% – 100%) was observed across the timeline. However, the highest rates of susceptibility were maintained for gentamicin, sulphamethoxazole-trimethoprim, kanamycin and chloramphenicol. We report an increase
in multidrug resistance (MDR) of 14.2% – 50% with an increase in resistotypes and plasmid profiles across the timeline. Eleven plasmid profiles were obtained in the 37 isolates studied with a minority of isolates (21.6%, 8/37) harbouring a 54 kb plasmid, commonly serovarspecific. A concerning increase in antimicrobial resistance to commonly administered drugs
was observed across the timeline. The surge in MDR is of great concern and implies the need for consistent antimicrobial stewardship. No correlation was observed between the plasmid and antibiotic profiles.
Description
This is a journal article.
Keywords
Antimicrobial resistance, Salmonella enteritidis
Citation
Khumalo, J., Saidi, B. and Mbanga, J., 2014. ‘Evolution of antimicrobial resistance of Salmonella enteritidis (1972–2005)’, Onderstepoort Journal of Veterinary Research 81(1), pp. 1-6.