Evolution of antimicrobial resistance of Salmonella enteritidis (1972–2005)

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dc.contributor.authorKhumalo, Jermaine
dc.contributor.authorSaidi, Bamusi
dc.contributor.authorMbanga, Joshua
dc.date.accessioned2014-12-17T07:16:54Z
dc.date.accessioned2023-06-23T14:00:28Z
dc.date.available2014-12-17T07:16:54Z
dc.date.available2023-06-23T14:00:28Z
dc.date.issued2014-11-12
dc.descriptionThis is a journal article.en_US
dc.description.abstractWith the extensive use of antibiotics in livestock production, surveillance revealed an increase in salmonella resistance to the commonly used antimicrobials in veterinary and public health. This serious threat to health care is further exacerbated by the limited epidemiological information about the common zoonotic agent, Salmonella enteritidis, required to determine antibiotic therapy. The aim was to characterise the antimicrobial resistance patterns of S. enteritidis isolates across different timelines (1972–2005) with accompanying genetic changes being investigated. Thirty-seven stored S. enteritidis isolates were collected from the Central Veterinary Laboratory, Harare, with antimicrobial susceptibility determined against eight antibiotics. Plasmids were isolated to analyse any genetic variation. An overall significant increase in resistance (p < 0.05) to nalidixic acid (0% – 10%), ampicillin (14.3% –50%), tetracycline (14.3% – 30%) and erythromycin (71.4% – 100%) was observed across the timeline. However, the highest rates of susceptibility were maintained for gentamicin, sulphamethoxazole-trimethoprim, kanamycin and chloramphenicol. We report an increase in multidrug resistance (MDR) of 14.2% – 50% with an increase in resistotypes and plasmid profiles across the timeline. Eleven plasmid profiles were obtained in the 37 isolates studied with a minority of isolates (21.6%, 8/37) harbouring a 54 kb plasmid, commonly serovarspecific. A concerning increase in antimicrobial resistance to commonly administered drugs was observed across the timeline. The surge in MDR is of great concern and implies the need for consistent antimicrobial stewardship. No correlation was observed between the plasmid and antibiotic profiles.en_US
dc.identifier.citationKhumalo, J., Saidi, B. and Mbanga, J., 2014. ‘Evolution of antimicrobial resistance of Salmonella enteritidis (1972–2005)’, Onderstepoort Journal of Veterinary Research 81(1), pp. 1-6.en_US
dc.identifier.otherdoi: 10.4102/ojvr.v81i1.807
dc.identifier.urihttp://196.220.97.103:4000/handle/123456789/453
dc.language.isoenen_US
dc.publisherAOSIS OpenJournalsen_US
dc.rights.licenseThis article was downloaded from NUST Institutional repository, and is made available under the terms and conditions as set out in the Institutional Repository Policy.en_US
dc.subjectAntimicrobial resistanceen_US
dc.subjectSalmonella enteritidisen_US
dc.titleEvolution of antimicrobial resistance of Salmonella enteritidis (1972–2005)en_US
dc.typeArticleen_US
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