Antimalarial Phytochemicals: Delineation of the Triterpene Asiatic Acid Malarial Anti-Disease and Pathophysiological Remedial Activities - Part I

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dc.contributor.authorMavondo, Greanious Alfred
dc.contributor.authorKasvosve, Ishmael
dc.date.accessioned2018-07-04T08:06:13Z
dc.date.accessioned2023-06-27T08:51:23Z
dc.date.available2018-07-04T08:06:13Z
dc.date.available2023-06-27T08:51:23Z
dc.date.issued2018-05
dc.descriptionReview articleen_US
dc.description.abstractMalaria is a composite condition of the Plasmodium parasite infection and accompanying pathologies. Parasite induced red blood cell perturbations and immunological response to infection drive various organ-specific syndromes accounting for a huge percentage of deaths amongst children <5 years and pregnant women. The multi-factorial pathophysiology includes acute renal failure, hypoglycaemia, severe malaria anaemia, acute respiratory distress syndrome/ acute lung injury and cerebral malaria as some of the prominent presentations of the disease. Current malaria treatment has largely remained “anti-parasite” or “anti-infection” necessitating discovery of “anti-disease” drugs that will ameliorate immunological aberrations, inflammation and metabolic disturbances which are ultimately the cause of high morbidity and mortality. Asiatic acid, a phytochemical, has well known curative properties on other conditions which share disease manifestations with malaria. However, the influence of Asiatic acid on malaria has not yet been reported. This review unravels the different facets of Asiatic acid and their possible remedial effects on molecular and biological changes introduced by the disease with emphasis on how this relates to glucose metabolism, acute renal failure, severe malaria anaemia, acute respiratory distress syndrome/ acute lung injury and cerebral malaria.en_US
dc.identifier.citationMavondo, G. A., Kasvosve, I., 2017. Antimalarial Phytochemicals: Delineation of the Triterpene Asiatic Acid Malarial Anti-Disease and Pathophysiological Remedial Activities - Part I. J Infect Disease Pathol 1: 104en_US
dc.identifier.urihttp://www.scholarena.com
dc.identifier.urihttp://196.220.97.103:4000/handle/123456789/902
dc.language.isoen_USen_US
dc.publisherScholarenaen_US
dc.subjectAsiatic Aciden_US
dc.subjectPhytochemicalen_US
dc.subjectMalariaen_US
dc.subjectAnti-Diseaseen_US
dc.subjectAntioxidanten_US
dc.subjectAnt-Parasiticen_US
dc.subjectAnti-Diseaseen_US
dc.titleAntimalarial Phytochemicals: Delineation of the Triterpene Asiatic Acid Malarial Anti-Disease and Pathophysiological Remedial Activities - Part Ien_US
dc.typeArticleen_US
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