Malaria Disease Perspective and an Opinion: Should Malaria Treatment Target the Parasite or the Malarial Pathophysiology Generated by the Parasite or Both?
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Date
2017-04-15
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
EC MICROBIOLOGY
Abstract
The malaria disease is caused by primarily four protozoan microorganisms of the Plasmodium genus transmitted by the female Anopheles
mosquito namely: P. falciparum, P. vivax, P. Malariae, P. ovalae. A fourth one, P. knowlesi is known natural pathogen of the marquis but
can also infect human. With its ability to infect both mature and immature red blood cells (RBC’s), multiply rapidly, cause severe malaria
anaemia (SMA), adhere to blood vessels endothelium, cause cerebral malaria, P. falciparum causes the most complications of the disease
with high fatality rates. The most prevalent human malaria parasite is P. vivax with a propensity to relapse when dormant liver stages
(hypnozoites) are activate to reinvade RBC’s many months to years after the initial malarial infection. The other parasites cause varying
disease manifestation with less fatalities.
Description
Journal article
Keywords
malaria disease, Malarial Pathophysiology, Parasite
Citation
Mavondo, G.A. 2017. Malaria Disease Perspective and an Opinion: Should Malaria Treatment Target the Parasite or the Malarial Pathophysiology Generated by the Parasite or Both?. EC MICROBIOLOGY. 7(5):149-154.