Effects of phenobarbital and 3-methylcholanthrene pretreatment on the pharmacokinetics of praziquantel in rats.

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dc.contributor.authorMasimirembwa, Collen M.
dc.contributor.authorNaik, Yogeshkumar S.
dc.contributor.authorHasler, Julia A.
dc.date.accessioned2014-03-28T08:29:09Z
dc.date.accessioned2023-06-23T14:00:38Z
dc.date.available2014-03-28T08:29:09Z
dc.date.available2023-06-23T14:00:38Z
dc.date.issued1992-06-25
dc.descriptionAn article with illustrations.en_US
dc.description.abstractThe effects of phenobarbital (PB) and 3-methylcholanthrene (MC) pretreatment on the phannac~kinetics of praziquantel (PZQ), a schistosomicide were studied in Spnrgue-Dawley rats. Blood samples at different time intervals were obtained by severing the tail vein and were analyzed for unchanged PZQ by HPLC. The PB-pretreated rats showed a &fold decrtase in AUC, a 5-fold decrease in Cmax and an 8-fold increase in Ch compared to the saline treated controls. The MC-pretreated rats and their oliveoil treated controls did not show any statistically significant diffmnces in the above parameters. These results suggest that PZQ is extensively metabolised by PB-inducible cytochrome P-450 isoforms and not by MC-inducible isoforms. These findings also suggest that the bioavailability of praziquantel could be altered to a significant extent in humans taking drugs that are phenobarbital type inducers.en_US
dc.description.sponsorshipResearch Board of the University of Zimbabwe and the International Programme in the Chemical Sciences, Sweden.en_US
dc.identifier.citationMasimirembwa C.M, Naik Y.S and Hasler J.A. (1993) Effects of phenobarbital and 3-methylcholanthrene pretreatment on the pharmacokinetics of praziquantel in rats.en_US
dc.identifier.urihttp://196.220.97.103:4000/handle/123456789/391
dc.language.isoenen_US
dc.relation.ispartofseriesEuropean Journal of Drug Metabolism and Pharmacokinetics;3
dc.rights.licenseThis article was downloaded from NUST Institutional repository, and is made available under the terms and conditions as set out in the Institutional Repository Policy.en_US
dc.subjectPraziquanteen_US
dc.subjectpharmacokineticsen_US
dc.subjectphenobarbitalen_US
dc.subject3-methylcholanthreneen_US
dc.subjectcytochrome P450 inductionen_US
dc.titleEffects of phenobarbital and 3-methylcholanthrene pretreatment on the pharmacokinetics of praziquantel in rats.en_US
dc.typeArticleen_US
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