Effect of schistosome infection on hepatic drug metabolising enzymes
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Date
1998-06
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Abstract
Schistosomiasis is a parasitic disease that affects over 200 million
persons worldwide.' The disease is caused by infection with
any one of several species that are known to affect humans.
Infected persons are likely to be consuming a wide spectrum of
xenobiotics such as drugs and environmental toxins. The drugs
consumed would not only include praziquantel and other schistosomicides,
but also those used for the treatment of other parasitic
diseases such as antimalarials, anthelmintics and antibiotics.
Experiments involving humans and experimental animals suggest
that infection with schistosomes causes a reduction in the
host's ability to metabolise and remove drugs from the b~dy.~.~
The metabolic fate of drugs is dependent to a large extent on
the expression and activity of the microsomal drug metabolising
enzyme^.^^^ These enzymes include the microsomal cytochrome
P-450 dependent monooxygenase system and the uridine diphosphate
glucuronosyl transferases as well as other cytosolic
enzymes such as glutathione S-transferases. This article reviews
the effects of experimental Schistosoma mansoni infection on
hepatic drug metabolising enzyme activity.
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Keywords
Schistosomiasis, hepatic drug metabolising enzymes
Citation
Naik, Y.S. and Hsler, J.A. (1998). Effect of schistosome infection on hepatic drug metabolising enzymes. South African Journal of Science Vol. 94.