Effect of schistosome infection on hepatic drug metabolising enzymes

Simple item page
dc.contributor.authorNaik, Yogeshkumar S.
dc.contributor.authorHasler, Julia A.
dc.date.accessioned2014-03-28T08:34:41Z
dc.date.accessioned2023-06-23T14:00:27Z
dc.date.available2014-03-28T08:34:41Z
dc.date.available2023-06-23T14:00:27Z
dc.date.issued1998-06
dc.description.abstractSchistosomiasis is a parasitic disease that affects over 200 million persons worldwide.' The disease is caused by infection with any one of several species that are known to affect humans. Infected persons are likely to be consuming a wide spectrum of xenobiotics such as drugs and environmental toxins. The drugs consumed would not only include praziquantel and other schistosomicides, but also those used for the treatment of other parasitic diseases such as antimalarials, anthelmintics and antibiotics. Experiments involving humans and experimental animals suggest that infection with schistosomes causes a reduction in the host's ability to metabolise and remove drugs from the b~dy.~.~ The metabolic fate of drugs is dependent to a large extent on the expression and activity of the microsomal drug metabolising enzyme^.^^^ These enzymes include the microsomal cytochrome P-450 dependent monooxygenase system and the uridine diphosphate glucuronosyl transferases as well as other cytosolic enzymes such as glutathione S-transferases. This article reviews the effects of experimental Schistosoma mansoni infection on hepatic drug metabolising enzyme activity.en_US
dc.description.sponsorshipResearch Board, University of Zimbabwe, and the International Programs in the Chemical Sciences, Uppsala, Sweden.en_US
dc.identifier.citationNaik, Y.S. and Hsler, J.A. (1998). Effect of schistosome infection on hepatic drug metabolising enzymes. South African Journal of Science Vol. 94.en_US
dc.identifier.urihttp://196.220.97.103:4000/handle/123456789/392
dc.language.isoenen_US
dc.rights.licenseThis article was downloaded from NUST Institutional repository, and is made available under the terms and conditions as set out in the Institutional Repository Policy.en_US
dc.subjectSchistosomiasisen_US
dc.subjecthepatic drug metabolising enzymesen_US
dc.titleEffect of schistosome infection on hepatic drug metabolising enzymesen_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Biochemical pathways in parasites.pdf
Size:
4.54 MB
Format:
Adobe Portable Document Format
Description:
Effect of schistosome infection on hepatic drug metabolising enzymes
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.71 KB
Format:
Plain Text
Description:
Download
Collections
Applied Biology and Biochemistry Publications