Effects of chloroquine treatment on antioxidant enzymes in rat liver and kidney.

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dc.contributor.authorMagwere, Tapiwanashe
dc.contributor.authorNaik, Yogeshkumar S.
dc.contributor.authorHasler, Julia A.
dc.date.accessioned2015-04-09T10:40:57Z
dc.date.accessioned2023-06-23T14:00:28Z
dc.date.available2015-04-09T10:40:57Z
dc.date.available2023-06-23T14:00:28Z
dc.date.issued1996-05-09
dc.descriptionA journal article with illustrationsen_US
dc.description.abstractThe effect of chloroquine (CHQ) administration on antioxidant enzymes in rat liver and kidney was studied. Male Sprague-Dawley rats were administered 20 mglkg CHQ once a week for 4 weeks (chronic treatment) or a single dose at 10 or 20 mglkg (acute treatment). Antioxidant enzyme activities were determined in cytosolic fractions of liver and kidney, whereas reduced glutathione (GSH) and malondialdehyde (MDA) were determined in tissue samples. Results indicate minimal effects of acute CHQ treatment, whereas chronic treatment with CHQ differentially affected antioxidant enzymes in the two organs. Superoxide dismutase activity was increased nearly twofold, while activities of selenium glutathione peroxidase (GPX), catalase, and NAD (P) H: quinone oxidoreductase were decreased in livers of CHQ-treated rats compared to controls. No significant effects of CHQ on glutathione reductase, GSH, and MDA levels were seen in the liver. Fewer effects of CHQ were observed in the kidney where a decrease in GPX activity and an increase in MDA levels was seen. Lowering of antioxidant enzymes activities in the liver by CHQ could render the organ more susceptible to subsequent oxidative stress; while increased MDA production after CHQ treatment in the kidney indicate that the organ is being subjected to oxidative stress. This could have implications for prolonged chloroquine intake.en_US
dc.description.sponsorshipInternational Programme in the Chemical Sciences (IPICS), Uppsala University, Sweden, and the University of Zimbabwe Research Board.en_US
dc.identifier.citationMagwere T, Naik Y.S, Hasler A. J. (1996) Effects of chloroquine treatment on antioxidant enzymes in rat liver and kidney.Elsevier Inc.en_US
dc.identifier.otherD.O.I: 0891-5849/97
dc.identifier.urihttp://196.220.97.103:4000/handle/123456789/495
dc.language.isoenen_US
dc.publisherElsevier Inc.en_US
dc.relation.ispartofseriesFree Radical Biology & Medicine;321-327
dc.rights.licenseThis article was downloaded from NUST Institutional repository, and is made available under the terms and conditions as set out in the Institutional Repository Policy.en_US
dc.subjectAntioxidant enzymesen_US
dc.subjectChloroquineen_US
dc.subjectOxidative stressen_US
dc.subjectLiveren_US
dc.subjectKidneyen_US
dc.subjectRatsen_US
dc.subjectFree radicalsen_US
dc.titleEffects of chloroquine treatment on antioxidant enzymes in rat liver and kidney.en_US
dc.typeArticleen_US
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